A Noninvasive Method for Assessing Muscular Health in an Aging Population

  • Research

Bioelectrical impedance analysis enables quick and easy monitoring of muscular health, addressing the impact of aging and conditions such as sarcopenia

As individuals age, maintaining muscular health becomes increasingly crucial, where the loss of muscle mass and strength is linked to a higher risk of falls and reduced physical activity. Now, researchers from Japan have developed a practical and accessible muscular health monitoring system based on phase angle measurements currently used to monitor body composition. This method can play a pivotal role in promoting overall well-being for the older population.

赤木先生 英文リリース

Title: Bioelectrical impedance analysis as a convenient method for monitoring muscular health

Caption: As individuals age, they are more at risk of losing muscle. By providing them with a means to quickly assess muscular health with phase angle measurements, individuals can take proactive steps to promote muscle health, such as engaging in physical activity and maintaining proper nutrition.

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As global life expectancies rise, the World Health Organization projects that by 2050, the global population aged 60 years and older will double to 2.1 billion from 1 billion in 2020—a trend particularly notable in Japan, which has the highest percentage of people aged 65 years and older. In 2022, 29.1% of the population was 65 years or older (expected to rise to 34.8% by 2040). The increase in the aging population comes with new health challenges, such as the need to assess muscular health.

The loss of muscle mass and strength could lead to a higher risk of falls, inactivity, confinement to bed, and metabolic problems,” says Professor Ryota Akagi from Shibaura Institute of Technology, who has been researching ways to quickly and non-invasively measure muscle response and coordination.

Now, Prof. Akagi, along with Dr. Kosuke Hirata from the University of Tsukuba; Dr. Yosuke Yamada from the National Institutes of Biomedical Innovation, Health and Nutrition; and Dr. Tsukasa Yoshida from the National Institutes of Biomedical Innovation have shown that bioelectrical impedance analysis (BIA), a technique widely used to assess body composition can also be used for measuring voluntary and evoked muscle contractions, which are integral to our ability to move, maintain stability, and respond to external stimuli. Their study lays the foundations for a convenient muscular health monitoring system; the corresponding findings were published on 23 November 2023 in Volume 14 of the journal Frontiers in Physiology.

BIA involves sending a safe electrical current through the body and measuring the impedance, characterized by resistance and reactance, where higher water and electrolyte concentrations lead to lower resistance and healthy cell membranes show higher reactance; these components are represented as phase angles calculated as a ratio of reactance and resistance [arctangent (reactance/resistance) × (180°/π)], where larger angles indicate higher muscle content.

To explore if the phase angle can serve as an indicator for other neuromuscular factors, the researchers examined its relationship with the neuromuscular properties of the leg, including a rapid force generation ability, intrinsic contractile properties, and overall neuromuscular activity in the plantar flexors of 60 participants aged 21–83 years.

Plantar flexors are a group of muscles located in the calf region and are essential for walking, running, jumping, and maintaining balance. “We aimed to clarify the association of phase angle obtained from the leg using BIA with voluntary muscle strength, twitch contractile properties, and neuromuscular activity,” says Assistant Prof. Hirata.

Muscle strength is the maximum force that muscles can generate during a voluntary contraction, while twitch contractile refers to how a muscle responds to an electrical stimulus. These measurements represent the ability of a muscle to contract, generate force, and contribute to movement. The findings revealed that the leg phase angle could estimate muscle contractile properties. Individuals with larger phase angles had better muscle function and generated more force. However, the researchers did not observe any between phase angle and neuromuscular activity.

These results indicate that the phase angle can be a valuable tool for estimating muscular health among individuals—such a system could find use in weight scales for a quick and easy physical assessment.

Because phase angle can be measured even by impedance analyzer for home use, such as weighing scales with body composition analyzer, phase angle may be the way to monitor muscular health easily and quickly. If possible, segment-level phase angle measurement can be conducted even by impedance analyzer for home use,” says Prof. Akagi.

As the population ages and conditions like sarcopenia, involving muscle loss, become more prevalent, insights into muscular health will assist individuals in taking proactive measures and enable countries to develop policies prioritizing the muscular health of the older population.



Title of original paper:

Relation of leg phase angle from bioelectrical impedance analysis with voluntary and evoked contractile properties of the plantar flexors


Frontiers in Physiology

Article link: 10.3389/fphys.2023.1292778 


About Professor Ryota Akagi from Shibaura Institute of Technology, Japan

Dr. Ryota Akagi is a Professor at the College of Systems Engineering and Science, Shibaura Institute of Technology, where he researches muscle mechanics, biomechanics, and sports science. He heads the Biomechanism laboratory at the University, which aims to examine muscle fatigue and develop effective training and stretching programs to improve overall health and prevent disorders. He has published over 88 papers in nutrition, health, and sports science.


About Assistant Professor Kosuke Hirata from the University of Tsukuba, Japan

Dr. Kosuke Hirata is an Assistant Professor at the Institute of Health and Sport Sciences, University of Tsukuba. He heads the Applied Anatomy Laboratory at the University, which aims to examine human neuromuscular function and joint flexibility to improve athletic performance and overall health. His research interests include life and sports science, and he has authored over 50 related research publications.


About Dr. Yosuke Yamada from the National Institutes of Biomedical Innovation, Health and Nutrition, Japan

Dr. Yosuke Yamada is Head of the Section of Exercise Guideline at the National Institutes of Biomedical Innovation, Health and Nutrition. His research interests include sports, exercise physiology, gerontology, and applied nutrition. He has published over 200 papers related to these areas.

Funding Information

This work was supported by JSPS KAKENHI Grant Number JP17KK0174.